Identification of Toxoplasma Gondii Tyrosine Hydroxylase (TH) Activity and Molecular Immunoprotection against Toxoplasmosis
نویسندگان
چکیده
منابع مشابه
Toxoplasma gondii and ocular toxoplasmosis: pathogenesis.
The protozoan Toxoplasma gondii is an obligate intracellular parasite that can infect any warm blooded animal,' as well as reptiles and fish,2' and shows a high incidence in humans, with approximately 500 million people throughout the world having antibodies to Tgondii.5 The organism is ubiquitous in nature and produces one of the most common infections ofhumans.' It is the most common cause of...
متن کاملMolecular Identification of Toxoplasma gondii in the Native Slaughtered Cattle of Tehran Province, Iran
Background: Toxoplasmosis, caused by Toxoplasma gondii, is a common parasitic disease, affecting almost one-third of the world’s population. It is transmitted by ingestion of food or water contaminated with oocysts excreted by cats and the consumption of raw or undercooked meat from ruminants. This study aimed at molecular characterization of T. gondii in native cattle from West of Tehran, Iran...
متن کاملA Unique Dual Activity Amino Acid Hydroxylase in Toxoplasma gondii
The genome of the protozoan parasite Toxoplasma gondii was found to contain two genes encoding tyrosine hydroxylase; that produces L-DOPA. The encoded enzymes metabolize phenylalanine as well as tyrosine with substrate preference for tyrosine. Thus the enzymes catabolize phenylalanine to tyrosine and tyrosine to L-DOPA. The catalytic domain descriptive of this class of enzymes is conserved with...
متن کاملovine and caprine toxoplasmosis (toxoplasma gondii)
toxoplasmosis, caused by toxoplasma gondii (t. gondii), is an economically important disease of livestock, especially sheep and goats, where it can cause early embryonic death and resorption, fetal death and mummification, abortion, stillbirth, and neonatal death.cats are the main reservoir for the toxoplasmosis which can contaminate the environments of other animal and human beings by their fa...
متن کاملThe temperature-sensitive mutants of Toxoplasma gondii and ocular toxoplasmosis.
The risk of blindness caused by ocular toxoplasmosis supports efforts to improve our understanding for control of this disease. In this study, the involvement of CD8(+), CD4(+), B cell, and IL-10 gene in the immune response of primary ocular infection with the temperature-sensitive mutant (ts-4) of the RH Toxoplasma gondii strain, and in the protective immunity of ocular ts-4 vaccination and ch...
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ژورنال
عنوان ژورنال: Vaccines
سال: 2020
ISSN: 2076-393X
DOI: 10.3390/vaccines8020158